The Effect of Coronavirus Disease 2019 on Reproduction System and Fertility

As of October 9, 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was recorded to have infected more than 235 countries and 36,361,054 people globally, 1,056,186 died from disease 2019 (COVID-19). In early it reported that the rate increase in new cases reached 300,000 per day. A scientific reference source about COVID-19 pregnancy fertility system based on results previous research. By conducting a literature search carried out until 12, through PubMed Google Scholar databases using keyword pregnancy, 20 articles were used as source. Human SARS-CoV appeared China, causing deadly epidemic 18 years ago. Novel coronavirus-2019 infects target cells by binding angiotensin-converting enzyme (ACE2) its surface spike protein. nCoV-2 modulates ACE2 expression causes serious injury, similar SARS-CoV. There is possibility SARS-CoV-2 mechanism can affect female, namely, harm ovarian tissue granulosa cells, reduce function quality oocytes, make infertility or miscarriage; also damage endometrial epithelium embryo implantation. caused which an infectious mostly affects system, but attack reproductive system.